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Gary Cornell on Serious Dangers from Chloroquine and Hydroxychloroquine for Diabetics Taking Metformin and from Other Bad Drug Interactions

Summary:
This is a guest post by Gary Cornell. Gary holds a Ph.D. in mathematics from Brown University and was the co-founder of the the major technical publisher Apress. He has written or co-written numerous best selling programming books and has been a Mathematics professor, a visiting scientist at IBM’s Watson Labs and a program director at the National Science Foundation. I’m not a doctor nor do I play one at daily press briefings. But like most mathematicians, I do know something about basic statistics. And, like most academics, I read everything that comes out about drugs I am taking. Obviously, I concentrate on the statistical sections and the list of side effects and drug interactions in these research papers. And so, this being 2020, I have a google alert for the drugs I am taking.

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This is a guest post by Gary Cornell. Gary holds a Ph.D. in mathematics from Brown University and was the co-founder of the the major technical publisher Apress. He has written or co-written numerous best selling programming books and has been a Mathematics professor, a visiting scientist at IBM’s Watson Labs and a program director at the National Science Foundation.

I’m not a doctor nor do I play one at daily press briefings. But like most mathematicians, I do know something about basic statistics. And, like most academics, I read everything that comes out about drugs I am taking. Obviously, I concentrate on the statistical sections and the list of side effects and drug interactions in these research papers. And so, this being 2020, I have a google alert for the drugs I am taking.

Anyway, one drug I am taking is the maximum dose of metformin. It is the fourth most prescribed drug in the United States and is used by more than 150,000,000 people world wide. It is the usual first drug prescribed for Type 2 diabetes. It is a good drug, the side effects are usually mild and it is even being explored (the TAME trial) as a possible “longevity” drug. A good drug…

So I was shocked to see this link popping up in my in box:

This note is from researchers  at Johns Hopkins – which I hasten to point out is currently rated the #2 school in the United States for “medical research”. People there are not general considered practitioners of psycho ceramics, in other words.

Holy ^&%$#, I thought. And then I tuned in to the Sunday “briefing” where Trump doubled down on his pushing claiming that “what do you have to lose” – and prevented Fauci from tempering his response. Though mice results aren’t conclusive and perhaps fatalities are off by a factor of 10 or a 100. Who the &^%$ knows if taking this will kill me? Maybe it is much worse for people on the maximum dose of metformin like me. But, absent proof it is safe for people taking metformin, pushing it if you are taking metformin except in life or death situations would seem to me malpractice for a doctor and practically criminal for an economist or politician.

Oh, in case you are thinking that maybe except for people taking metformin, hydroxychloroquine is a “good” drug, Drugs.com says there are 332 drug interactions (59 of them being major). And here is the list of side effects

So, answer is, you have a lot to lose.

Miles Kimball
Miles Kimball is Professor of Economics and Survey Research at the University of Michigan. Politically, Miles is an independent who grew up in an apolitical family. He holds many strong opinions—open to revision in response to cogent arguments—that do not line up neatly with either the Republican or Democratic Party.

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